rs2967678

This is a downstream gene variant variant in the NFILZ gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mosquito bite reaction itch intensity measurement

Jones AV et al. “GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.” Human Molecular Genetics 26(7):1391-1406 (2017)

Allele T

OR 0.04

p 4.0e-15

N 84,724

Large GWAS

European

basophil measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.03

p 7.0e-12

N 330,024

Major Consortium StudyLarge GWAS

multi-ancestry

About NFILZ

Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in circadian rhythm and regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all NFILZ variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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