rs307377

neutralMag 2.0

This is a protein-altering variant in the TAS1R3 gene.

Key Literature Trait Associations

Umami Taste Sensitivity

TAS1R3 encodes a subunit of the TAS1R1/TAS1R3 heterodimeric receptor that mediates umami (L-glutamate) taste perception. The rs307377 T allele (Ala110Val) alters the extracellular venus flytrap domain of TAS1R3, reducing receptor sensitivity to monosodium glutamate. In a study of 242 Japanese subjects, carriers of the T allele showed significantly lower umami taste sensitivity scores compared to CC homozygotes (p = 0.009).

Chen QY et al. “Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.” The American Journal of Clinical Nutrition (2009)

Allele T

OR —

p —

N 242

Candidate gene study

multi-ancestry

Kim HS et al. “Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study.” Journal of Clinical Gastroenterology 43(5):482-488 (2009)

Allele T

OR —

p 9.0e-3

Candidate gene study

Shigemura N et al. “Genetic and molecular basis of individual differences in human umami taste perception.” Plos One (2009)

Allele T

OR —

p —

N 254

Candidate gene study

Japanese

Raliou M et al. “Tas1R1-Tas1R3 taste receptor variants in human fungiform papillae.” Neuroscience Letters (2009)

Allele T

OR —

p —

Candidate gene study

European

Gene information from NCBI Gene. Variant classifications from ClinVar.

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