rs307821

This is a variant in the FLT4 gene that changes a arginine to an leucine.

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ClinVar annotation

Benign★☆☆☆
4 submitters1 publication

not specified

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Research that mentions this SNP (1)

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Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients
AssociationN=121Juana Dornbusch et al.(2016)· Journal of Cancer Research and Clinical Oncology

This retrospective cohort study of 121 metastatic renal cell carcinoma (mRCC) patients treated with sunitinib evaluated 10 SNPs in angiogenesis-related genes (VEGFA, VEGFR1, VEGFR2, VEGFR3) as prognostic markers. Kaplan-Meier and Cox regression analyses identified rs9582036 in VEGFR1 (AA/AC genotypes vs CC wild-type) as significantly associated with improved overall survival (HR=0.241, p=0.018), while rs699947 in VEGFA showed associations with progression-free survival. No significant associations were found between SNPs and sunitinib-induced adverse effects (hand-foot syndrome, hypertension) after multiple testing correction.

Traits studied:hand-foot syndromehypertensionmetastatic renal cell carcinoma (mRCC)overall survivalprogression-free survivalsunitinib response
PubMedDOIMetascience Observatory

About FLT4

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

View all FLT4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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