rs3088442
This variant is located in the SLC22A3 gene.
▶Research that mentions this SNP (1)
▶Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancerAssociationN=670Anjing Ren et al.(2019)· International Journal of Cancer
This case-control study investigated the association between three SLC22A3 SNPs (rs555754, rs3123636, rs3088442) and type 2 diabetes mellitus susceptibility in 450 Chinese T2DM patients and 220 healthy controls. The rs555754 A allele increased T2DM risk (OR=1.409, p=0.023), while rs3123636 C allele was protective (OR=0.645, p=0.018). The AC haplotype of rs3088442-rs3123636 also showed protective association (OR=0.713, p=0.011).
About SLC22A3
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
View all SLC22A3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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