rs3091312
This is a downstream gene variant variant in the CCR3 gene.
▶Research that mentions this SNP (1)
▶The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian femalesAssociationN=1,048Fang Yang et al.(2007)· Human Genetics
This family-based association study of 1,048 Caucasian females from 354 nuclear families identified significant associations between CCR3 gene polymorphisms and age at menarche (AAM). SNP7 and SNP9 showed significant total associations with AAM (P = 0.009 and P = 0.006, respectively), and SNP9 also showed significant within-family association (P = 0.01). The haplotype AGA (formed by SNP7, SNP9, and SNP13) was significantly associated with AAM (P = 0.008) and explained 2.01% of phenotypic variation, with carriers delaying menarche by approximately 4 months compared to non-carriers.
About CCR3
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
View all CCR3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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