rs3099797
This is a intron variant variant in the NTM gene.
▶Research that mentions this SNP (1)
▶Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signalsMeta-analysisN=2,583Below JE et al.(2011)· Diabetologia
Genome-wide association study (GWAS) of type 2 diabetes in 837 Mexican-Americans cases and 436 controls from Starr County, Texas, combined with meta-analysis of 967 cases and 343 controls from Mexico City. The study identified 49 high-quality SNPs in 14 genomic regions associated with type 2 diabetes, including novel loci in PER3, PARD3B, EPHA4, TOMM7, PTPRD, and IL34. Top signals showed odds ratios ranging from 1.26 to 1.83. Functional annotation revealed significant enrichment of expression quantitative trait loci (eQTL) in muscle and adipose tissues among top associated variants.
About NTM
This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
View all NTM variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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