rs3104788

This variant is located in the CASC16 gene.

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Research that mentions this SNP (1)

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Prevalence and determinants of periodic limb movements in the general population
AssociationN=2,162José Haba‐Rubio et al.(2016)· Annals of Neurology

Population-based study of 2162 European adults assessing prevalence and genetic determinants of periodic limb movements during sleep (PLMS). PLMS with index >15/h was present in 28.6% of the population. Genome-wide association study and candidate gene analysis identified SNP rs3923809 in BTBD9 as showing genome-wide significant association (p=9.10e-10), with AA homozygotes showing almost threefold higher PLMS index than non-carriers. Additional significant associations found with rs3104788 (TOX3, p=1.98e-05) and rs2300478 (MEIS1, p=0.0452). In multivariate analysis, age, male gender, antidepressant use, RLS, and these three SNP variants were independent predictors of PLMSI >15/h.

Traits studied:Periodic limb movement disorder (PLMD)Periodic limb movements during sleep (PLMS)Restless legs syndrome (RLS)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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