rs3125734
This is a protein-altering variant in the RTKN2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
rheumatoid arthritis
Myouzen K et al. “Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.” Plos Genetics 8(9):e1002949 (2012)
Allele T
OR 1.20
p 5.0e-9
N 5,683
Large GWAS
East Asian
About RTKN2
Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of non-canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all RTKN2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…