rs3129843

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

myositis

Rothwell S et al. “Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.” Annals of the Rheumatic Diseases 75(8):1558-66 (2016)

Allele G

OR 2.74

p 9.0e-133

N 18,207

Large GWAS

European

dermatomyositis, juvenile dermatomyositis

Rothwell S et al. “Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.” Annals of the Rheumatic Diseases 75(8):1558-66 (2016)

Allele G

OR 2.18

p 2.0e-48

N 16,530

Large GWAS

European

omega-3 polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele G

OR —

p 1.0e-11

N 110,346

Large GWAS

European

Inguinal hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)

Allele A

OR 1.10

p 5.0e-8

N 275,546

Major Consortium StudyLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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