rs3131018

This is a regulatory region variant variant in the PSORS1C3 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neutrophil count

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele A

OR —

p 3.0e-21

N 234,802

Large GWAS

European

basophil count

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele A

OR —

p 2.0e-16

N 234,678

Large GWAS

European

HIV-1 infection

Pereyra F et al. “The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.” Science (new York, N.y.) 330(6010):1551-7 (2010)

Allele C

OR 2.10

p 4.0e-16

N 3,622

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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