rs3132584

This variant is located in the TUBB gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

handedness

Cuellar-Partida G et al. “Genome-wide association study identifies 48 common genetic variants associated with handedness.” Nature Human Behaviour 5(1):59-70 (2021)

Allele T

OR 0.95

p 6.0e-25

N 1,766,671

Large GWAS

European

BMI-adjusted waist-hip ratio

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)

Allele T

OR 0.02

p 3.0e-8

N 186,825

Major Consortium StudyLarge GWAS

European

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ClinVar annotation

Benign★☆☆☆

1 submitter

View on ClinVar →

About TUBB

This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]