rs3176326

▶

GWAS Catalog Trait Associations (18)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

QRS duration

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)

Allele A

OR 0.10

p 3.0e-173

N 60,343

Large GWAS

European, African unspecified, Hispanic or Latin American, South East Asian, South Asian

van Setten J et al. “Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.” European Journal of Human Genetics : Ejhg 27(6):952-962 (2019)

Allele A

OR 1.18

p 4.0e-25

N 25,509

Meta-analysisLarge GWAS

multi-ancestry

Swenson BR et al. “GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations.” Plos One 14(6):e0217796 (2019)

Allele A

OR 1.15

p 2.0e-19

N 15,124

Large GWAS

Hispanic or Latin American

JT interval

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)

Allele A

OR 0.07

p 4.0e-81

N 252,730

Large GWAS

European, African unspecified, Hispanic or Latin American, South East Asian, South Asian

atrial fibrillation

Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)

Allele A

OR 0.07

p 1.0e-68

N 2,584,013

Large GWAS

multi-ancestry

Miyazawa K et al. “Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.” Nature Genetics 55(2):187-197 (2023)

Allele A

OR 0.07

p 7.0e-20

N 2,339,188

Large GWAS

multi-ancestry

Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)

Allele A

OR 1.07

p 1.0e-34

N 1,650,345

Meta-analysisLarge GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele A

OR 0.01

p 5.0e-13

N 1,486,094

Large GWAS

European

Cárcel-Márquez J et al. “A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype.” Frontiers in Cardiovascular Medicine 9:940696 (2022)

Allele A

OR 0.01

p 5.0e-14

N 1,030,836

Large GWAS

European

Nielsen JB et al. “Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.” Nature Genetics 50(9):1234-1239 (2018)

Allele A

OR 1.06

p 1.0e-13

N 1,030,836

Large GWAS

European

Roselli C et al. “Multi-ethnic genome-wide association study for atrial fibrillation.” Nature Genetics 50(9):1225-1233 (2018)

Allele A

OR 1.06

p 8.0e-11

N 588,190

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.08

p 2.0e-31

N 437,772

Major Consortium StudyLarge GWAS

European

heart failure

Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)

Allele A

OR 0.07

p 4.0e-57

N 2,358,556

Large GWAS

multi-ancestry

Henry A et al. “Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.” Nature Genetics 57(4):815-828 (2025)

Allele A

OR 0.07

p 4.0e-32

N 1,968,806

Meta-analysisLarge GWAS

multi-ancestry

Rasooly D et al. “Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.” Nature Communications 14(1):3826 (2023)

Allele A

OR 0.07

p 3.0e-22

N 1,279,610

Large GWAS

European

Enzan N et al. “Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.” Nature Communications 16(1):9680 (2025)

Allele A

OR 0.10

p 1.0e-12

N 886,118

Large GWAS

multi-ancestry

hypertrophic cardiomyopathy

Tadros R et al. “Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.” Nature Genetics 57(3):530-538 (2025)

Allele A

OR 0.34

p 9.0e-45

N 28,106

Large GWAS

European, African unspecified, Hispanic or Latin American, East Asian, South Asian, NR

Harper AR et al. “Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.” Nature Genetics 53(2):135-142 (2021)

Allele A

OR 0.25

p 2.0e-11

N 50,266

Large GWAS

multi-ancestry

systolic heart failure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.13

p 7.0e-34

N 438,433

Major Consortium StudyLarge GWAS

European

congestive heart failure

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.09

p 2.0e-33

N 429,672

Major Consortium StudyLarge GWAS

European

dilated cardiomyopathy

Jurgens SJ et al. “Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.” Nature Genetics 56(12):2636-2645 (2024)

Allele A

OR 0.15

p 3.0e-19

N 955,733

Large GWAS

multi-ancestry

cardioverter defibrillator

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.15

p 1.0e-18

N 629,819

Major Consortium StudyLarge GWAS

multi-ancestry

QRS-T angle

Young WJ et al. “Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.” Nature Communications 14(1):1411 (2023)

Allele A

OR 0.04

p 3.0e-18

N 159,715

Large GWAS

European, African unspecified, Hispanic or Latin American

This variant is in our database but has no known associations or PRS memberships yet.

rs3176326

GWAS Catalog Trait Associations (18)

QRS duration

JT interval

atrial fibrillation

heart failure

hypertrophic cardiomyopathy

systolic heart failure

congestive heart failure

dilated cardiomyopathy

cardioverter defibrillator

QRS-T angle

Community Wiki

Comments