rs3219177

This is a downstream gene variant variant in the RETN gene.

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Research that mentions this SNP (2)

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Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population
AssociationN=3,133Asano H. et al.(2010)· Diabetologia

In an aged Japanese cohort of 3,133 participants from the KING study, plasma resistin concentration was significantly associated with two RETN polymorphisms: rs34861192 (the most prominent, explaining 35.9% of variance) and rs3745368. These variants independently determined resistin levels and resistin levels were associated with metabolic traits including dyslipidemia, insulin concentration, and obesity.

Traits studied:BMIDyslipidemiaHDL-cholesterolHypertensionInsulin resistanceObesityPlasma resistin concentrationSerum insulinTriacylglycerolType 2 diabetes
PubMedDOIMetascience Observatory
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Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects
AssociationN=1,190Conneely KN et al.(2004)· Diabetologia

This study examined four non-coding SNPs in the resistin gene (RETN) for association with Type 2 diabetes and related traits in a Finnish cohort of 781 diabetes cases and 409 controls. While the SNPs showed no significant association with Type 2 diabetes itself, the common CCG haplotype (rs1862513-rs3219177-rs3745367) was associated with increased weight, waist circumference, and diastolic blood pressure in cases, lower insulin sensitivity in spouse controls, and rs3745368 was associated with lower HDL cholesterol. The findings provide evidence that resistin gene variants are related to obesity and insulin resistance phenotypes.

Traits studied:Blood pressureBody mass indexHDL cholesterolInsulin resistanceInsulin sensitivityObesityType 2 diabetesWaist circumferenceWeight
PubMedDOIMetascience Observatory

About RETN

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020]

View all RETN variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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