rs33981382
This is a variant in the PADI4 gene that changes a tyrosine to an cysteine.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of protein-arginine deiminase type-4 in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.67
p 1.0e-114
N 47,745
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
4 submitters2 publicationsnot provided; not specified; Uterine corpus endometrial carcinoma; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia
View on ClinVar →About PADI4
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
View all PADI4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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