rs34163229
This is a protein-altering variant in the SYNPO2L gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heart failure
Rasooly D et al. “Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.” Nature Communications 14(1):3826 (2023)
Allele T
OR 0.06
p 7.0e-13
N 1,279,610
Large GWAS
European
left ventricular structural measurement
Ning C et al. “Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy.” Nature Communications 14(1):7900 (2023)
Allele T
OR 0.06
p 1.0e-9
N 42,122
Large GWAS
European
left ventricular mass index
Khurshid S et al. “Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass.” Nature Communications 14(1):1558 (2023)
Allele G
OR 0.60
p 1.0e-8
N 43,230
Large GWAS
multi-ancestry
About SYNPO2L
Predicted to enable actin binding activity. Predicted to be involved in several processes, including positive regulation of Rho protein signal transduction; positive regulation of stress fiber assembly; and sarcomere organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in Z disc; actin cytoskeleton; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all SYNPO2L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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