rs342293

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GWAS Catalog Trait Associations (104)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet component distribution width

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.10

p —

N 408,112

Large GWAS

European

platelet volume

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.16

p —

N 408,112

Large GWAS

European

Xiang R et al. “Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.” Nature Communications 16(1):4260 (2025)

Allele G

OR 0.02

p 4.0e-12

N 391,597

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.16

p —

N 164,454

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.14

p 1.0e-75

N 40,412

Major Consortium StudyLarge GWAS

Hispanic or Latin American

Little A et al. “Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative.” Human Molecular Genetics 31(3):347-361 (2022)

Allele G

OR 0.15

p 4.0e-57

N 23,485

Large GWAS

multi-ancestry

Hu Y et al. “Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.” Bmc Genomics 22(1):432 (2021)

Allele G

OR 0.11

p 5.0e-9

N 21,347

Large GWAS

Hispanic or Latin American

Gieger C et al. “New gene functions in megakaryopoiesis and platelet formation.” Nature 480(7376):201-8 (2011)

Allele G

OR 0.02

p 7.0e-57

N 18,600

Large GWAS

European

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR 0.14

p 5.0e-23

N 10,737

Large GWAS

African American or Afro-Caribbean, African unspecified

Khader Shameer et al. “A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects” Human Genetics (2014)

Allele G

OR 0.15

p 5.0e-22

N 6,291

Large GWAS

European

Read RW et al. “GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort.” Plos One 14(6):e0218078 (2019)

Allele G

OR 0.13

p 7.0e-11

N 4,675

Large GWAS

multi-ancestry

Soranzo N et al. “A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.” Nature Genetics 41(11):1182-90 (2009)

Allele G

OR 0.02

p 2.0e-33

N 4,627

Meta-analysisMajor Consortium Study

European

Soranzo N et al. “A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function.” Blood 113(16):3831-7 (2009)

Allele G

OR 0.02

p 1.0e-24

N 1,221

Large GWAS

European

platelet count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele G

OR —

p 1.0e-318

N 721,201

Large GWAS

multi-ancestry

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele G

OR 0.06

p 4.0e-256

N 928,679

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.03

p 5.0e-15

N 148,623

Large GWAS

East Asian

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 2.0e-18

N 55,712

Major Consortium StudyLarge GWAS

Hispanic or Latin American

Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)

Allele G

OR 0.07

p 5.0e-26

N 38,000

Large GWAS

South Asian

Qayyum R et al. “A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.” Plos Genetics 8(3):e1002491 (2012)

Allele G

OR 4.05

p 2.0e-8

N 16,388

Meta-analysisLarge GWAS

African American or Afro-Caribbean

synaptosomal-associated protein 25 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.15

p 1.0e-175

N 47,745

Large GWAS

European

immature platelet count

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.19

p 1.0e-155

N 36,618

Large GWAS

European

immature platelet measurement

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.19

p 3.0e-155

N 36,829

Large GWAS

European

level of dynamin-3 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.12

p 5.0e-92

N 47,745

Large GWAS

European

level of protein FAM13A in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.10

p 5.0e-68

N 47,745

Large GWAS

European

mothers against decapentaplegic homolog 3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.09

p 8.0e-56

N 47,745

Large GWAS

European

level of heat shock factor-binding protein 1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.07

p 8.0e-41

N 47,745

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs342293

GWAS Catalog Trait Associations (104)

platelet component distribution width

platelet volume

platelet count

synaptosomal-associated protein 25 measurement

immature platelet count

immature platelet measurement

level of dynamin-3 in blood

level of protein FAM13A in blood

mothers against decapentaplegic homolog 3 measurement

level of heat shock factor-binding protein 1 in blood

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