rs3448

This is a regulatory region variant variant in the RHOA gene.

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Research that mentions this SNP (2)

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Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence
AssociationN=568John P. Gerstenberger et al.(2015)· The Prostate

This candidate gene study examined 73 SNPs in 10 selenoprotein and antioxidant genes among 568 men with non-metastatic prostate cancer treated with radical prostatectomy. Plasma selenium was not associated with high-grade prostate cancer or recurrence. Less common alleles of rs11913319 (TXNRD2, OR=2.01) and rs125701 (OGG1, OR=1.72) were associated with increased risk of high-grade prostate cancer. Multiple SNPs in TXNRD1, TXNRD2, GPX3, and SEP15 showed associations with prostate cancer recurrence, though none remained significant after Bonferroni correction.

Traits studied:High-grade prostate cancerProstate cancer recurrence
PubMedDOIMetascience Observatory
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Variation in selenoenzyme genes and prostate cancer risk and survival
AssociationN=2,575Milan S. Geybels et al.(2013)· The Prostate

This candidate gene study examined associations between 35 common SNPs in seven selenoenzyme genes (GPX1-4, SEP15, SEPP1, TXNRD1) and prostate cancer risk and prostate cancer-specific mortality (PCSM) in 1,309 cases and 1,266 controls of European ancestry. Only GPX1 rs3448 remained significantly associated with overall prostate cancer risk (OR=0.62, 95% CI 0.44-0.88), and several SNPs showed stage/grade-dependent associations. Associations with PCSM were found for GPX4 and TXNRD1 variants, but none retained significance after multiple comparison adjustment.

Traits studied:prostate cancerprostate cancer risk by gradeprostate cancer risk by stageprostate cancer-specific mortality
PubMedDOIMetascience Observatory

About RHOA

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

View all RHOA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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