rs35087277

This variant is located in the FARSA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of eukaryotic-type phenylalanine--tRNA ligase alpha subunit in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.11

p 8.0e-12

N 47,745

Large GWAS

European

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ClinVar annotation

Benign

1 submitter

FARSA-related disorder

View on ClinVar →

About FARSA

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

View all FARSA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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