rs35098798
This variant is located in the PPP1R13B gene.
▶ClinVar annotation
Benign★★★☆
2 submitters2 publicationsAbout PPP1R13B
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
View all PPP1R13B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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