rs352046
This is a regulatory region variant variant in the CXCL5 gene.
▶Research that mentions this SNP (1)
▶CXCL5 Gene Polymorphism Association with Diabetes MellitusAssociationN=332Shirin Hasani Ranjbar et al.(2008)· Molecular Diagnosis & Therapy
This case-control study examined the association between the CXCL5 -156G>C promoter polymorphism (rs352046) and type 2 diabetes mellitus in an Iranian population of 230 diabetic patients and 102 healthy controls. The C allele was significantly associated with increased diabetes risk (OR=1.72, p=0.01), with carriers of G/C or C/C genotypes showing 2.17-fold higher risk compared to G/G (p=0.004). No association was found between this polymorphism and diabetic complications.
About CXCL5
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
View all CXCL5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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