rs35446936
This variant is located in the ACTRT3 gene.
▶GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
chromosome, telomeric region length
Liu WS et al. “Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications.” Geroscience 46(5):5365-5385 (2024)
Allele A
OR 0.09
p 1.0e-262
N 327,790
Large GWAS
European
Allaire P et al. “Genetic and clinical determinants of telomere length.” Hgg Advances 4(3):100201 (2023)
Allele A
OR 0.10
p 1.0e-44
N 62,271
Large GWAS
European
thyroid carcinoma
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele A
OR 0.12
p 2.0e-26
N 2,917,628
Large GWAS
multi-ancestry
erythrocyte count
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.02
p 1.0e-20
N 503,987
Large GWAS
multi-ancestry
Uterine leiomyoma
Sliz E et al. “Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata.” Nature Communications 14(1):542 (2023)
Allele A
OR 0.93
p 1.0e-16
N 367,903
Large GWAS
European
Pujol Gualdo N et al. “Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.” Nature Medicine 31(5):1626-1634 (2025)
Allele A
OR 1.05
p 8.0e-9
N 295,291
Large GWAS
European
skin lipoma
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.15
p 1.0e-13
N 441,079
Major Consortium StudyLarge GWAS
European
urinary bladder cancer
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.09
p 6.0e-13
N 627,011
Major Consortium StudyLarge GWAS
multi-ancestry
uterine fibroid
Gallagher CS et al. “Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.” Nature Communications 10(1):4857 (2019)
Allele A
OR 1.06
p 1.0e-8
N 244,324
Large GWAS
European
lipoma
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.12
p 3.0e-21
N 608,502
Major Consortium StudyLarge GWAS
multi-ancestry
About ACTRT3
Predicted to be located in cytoplasm; cytoskeleton; and male germ cell nucleus. Predicted to be active in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
View all ACTRT3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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