rs35570272

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

eosinophil count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele T

OR —

p 2.0e-52

N 583,850

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.03

p 2.0e-14

N 447,598

Major Consortium StudyLarge GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.02

p 6.0e-29

N 442,919

Large GWAS

multi-ancestry

atopic eczema

Budu-Aggrey A et al. “European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.” Nature Communications 14(1):6172 (2023)

Allele T

OR 1.03

p 2.0e-26

N 864,982

Meta-analysisLarge GWAS

European

asthma

Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)

Allele T

OR 0.04

p 3.0e-23

N 1,800,785

Meta-analysisLarge GWAS

multi-ancestry

Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)

Allele T

OR 1.05

p 3.0e-12

N 771,388

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.05

p 2.0e-14

N 625,448

Large GWAS

multi-ancestry

Valette K et al. “Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.” Communications Biology 4(1):700 (2021)

Allele T

OR 0.05

p 3.0e-14

N 408,422

Major Consortium StudyLarge GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.05

p 7.0e-16

N 394,626

Large GWAS

European

Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)

Allele T

OR 1.05

p 3.0e-15

N 394,283

Large GWAS

multi-ancestry

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)

Allele T

OR 1.07

p 3.0e-20

N 341,215

Large GWAS

European

Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)

Allele T

OR 1.05

p 2.0e-11

N 305,098

Large GWAS

multi-ancestry

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)

Allele T

OR 1.06

p 2.0e-21

N 303,859

Large GWAS

European

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)

Allele T

OR —

p 1.0e-15

N 281,699

Major Consortium StudyLarge GWAS

European

Inhalant adrenergic use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.05

p 2.0e-10

N 355,171

Large GWAS

multi-ancestry

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele T

OR 0.06

p 3.0e-9

N 176,445

Major Consortium StudyLarge GWAS

European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)

Allele T

OR 1.10

p 3.0e-10

N 327,670

Large GWAS

European

asthma, chronic obstructive pulmonary disease

John C et al. “Genetic Associations and Architecture of Asthma-COPD Overlap.” Chest 161(5):1155-1166 (2022)

Allele T

OR 1.10

p 2.0e-9

N 48,428

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs35570272

GWAS Catalog Trait Associations (6)

eosinophil count

atopic eczema

asthma

Inhalant adrenergic use measurement

childhood onset asthma

asthma, chronic obstructive pulmonary disease

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