rs356186
This is a intron variant variant in the SNCA gene.
▶Research that mentions this SNP (1)
▶Alpha‐synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: A meta‐analysisMeta-analysisWei Han et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This meta-analysis of 19 studies (comprising 31 case-control studies) examined 10 SNCA gene polymorphisms and Parkinson's disease (PD) risk. Eight SNPs showed significant associations with PD: rs181489 (OR 1.678, Caucasian), rs356186 (protective, OR 0.653, Caucasian), rs356219 (OR 1.523, Caucasian), rs894278 (OR 1.493, Asian), rs2583988 (OR 1.409, Caucasian), rs2619364 (OR 1.346, Caucasian), rs10005233 (OR 1.359 in dominant model, Caucasian), and rs11931074 (OR 1.798 overall). Two SNPs (rs2619363 and rs2737029) showed no significant association. Results indicate SNCA is a common susceptibility marker for PD in both Asian and Caucasian populations.
About SNCA
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
View all SNCA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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