rs35654957

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sex hormone-binding globulin measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)

Allele T

OR 0.01

p 5.0e-13

N 180,094

Large GWAS

European

alkaline phosphatase measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.01

p 8.0e-11

N 463,178

Large GWAS

multi-ancestry

Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)

Allele C

OR 5.64

p 2.0e-8

N 390,964

Large GWAS

multi-ancestry

femoral neck bone mineral density

Pei YF et al. “Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.” Bone 110:378-385 (2018)

Allele T

OR 0.05

p 4.0e-10

N 40,491

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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