rs35744813

neutralMag 3.2

This is a upstream gene variant variant in the TAS1R3 gene.

Key Literature Trait Associations

Sweet Taste Sensitivity

Each copy of the T allele at rs35744813, located 1,266 bp upstream of TAS1R3, reduces sucrose taste sensitivity by roughly 25%, with T/T homozygotes showing approximately 50% decreased sensitivity compared to C/C individuals. TAS1R3 encodes a subunit of the TAS1R2/TAS1R3 heterodimeric sweet taste receptor, and this promoter variant alters a cis-regulatory silencer element that lowers gene transcription. In a study of 144 individuals, rs35744813 alone explained ~16% of population variability in sucrose perception (Bonferroni-corrected p = 2 × 10⁻⁵).

Fushan AA et al. “Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose.” Current Biology : Cb 19(15):1288-1293 (2009)

Allele T

OR —

p 2.0e-5

Candidate gene study

Melo SV et al. “Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children.” Genetics and Molecular Biology (2017)

Allele T

OR —

p —

N 312

Candidate gene study

multi-ancestry

Han P et al. “TAS1R1 and TAS1R3 Polymorphisms Relate to Energy and Protein-Rich Food Choices from a Buffet Meal Respectively.” Nutrients (2018)

Allele T

OR —

p —

N 30

Candidate gene study

European

Gene information from NCBI Gene. Variant classifications from ClinVar.

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