rs35840638

This is a intron variant variant in the ADAP2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.04

p 3.0e-14

N 153,950

Large GWAS

East Asian

Uterine leiomyoma, estrogen-receptor positive breast cancer

Wu X et al. “Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis.” American Journal of Human Genetics 109(7):1272-1285 (2022)

Allele A

OR —

p 2.0e-12

N 478,454

Large GWAS

European

Uterine leiomyoma, estrogen-receptor negative breast cancer

Allele A

OR —

p 2.0e-9

N 430,421

Large GWAS

European

About ADAP2

The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]

rs35840638

GWAS Catalog Trait Associations (3)

body height

Uterine leiomyoma, estrogen-receptor positive breast cancer

Uterine leiomyoma, estrogen-receptor negative breast cancer

About ADAP2

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