rs35878037

This variant is located in the GPNMB gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

transmembrane glycoprotein NMB measurement

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele A

OR 1.04

p 1.0e-14

N 466

Small GWAS

African American or Afro-Caribbean

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ClinVar annotation

Benign★☆☆☆

1 submitter1 publication

View on ClinVar →

About GPNMB

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all GPNMB variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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