rs36010924

This is a upstream gene variant variant in the TCHH gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

balding measurement

Yap CX et al. “Dissection of genetic variation and evidence for pleiotropy in male pattern baldness.” Nature Communications 9(1):5407 (2018)

Allele G

OR 0.06

p 2.0e-53

N 205,327

Large GWAS

European

level of phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.06

p 3.0e-29

N 47,745

Large GWAS

European

About TCHH

The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017]

View all TCHH variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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