rs36015125

This is a intron variant variant in the FARSB gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

aging rate

Lee SG et al. “Identification of Genetic Loci Associated with Facial Wrinkles in a Large Korean Population.” The Journal of Investigative Dermatology 142(10):2824-2827 (2022)

Allele C

OR 0.89

p 2.0e-11

N 11,079

Large GWAS

East Asian

About FARSB

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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