rs36022820
This variant is located in the ADRA2A gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studiesMeta-analysisN=17,000Talmud PJ et al.(2011)· Diabetologia
Meta-analysis of four prospective UK cohort studies (>17,000 individuals) examining ADRA2A genetic variants and metabolic traits. rs553668 G>A was associated with increased type 2 diabetes risk (OR 1.17, 95% CI 1.04-1.31, p=0.01) and higher fasting glucose (0.03 mmol/l per allele, p=0.016). Secondary ADRA2A SNPs showed associations with blood pressure, BMI, and glucose-related phenotypes. Haplotype analysis identified a rare rs553668A/rs10885122T haplotype strongly associated with elevated fasting glucose.
About ADRA2A
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
View all ADRA2A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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