rs360719
This is a coding sequence variant variant in the IL18 gene.
▶Research that mentions this SNP (1)
▶IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high‐risk Chinese populationAssociationN=758Li Liu et al.(2011)· International Journal of Cancer
This case-control study of 518 hemodialysis patients and 240 controls investigates the association between IL12A (rs568408), IL12B (rs3212227), and IL18 (rs360719) gene polymorphisms and development of antibodies to hepatitis B virus surface antigen (anti-HBs). The rs360719 CC genotype was individually associated with increased anti-HBs development (p=0.009). Combined rs568408 AA and rs360719 TT genotypes showed a 10.9-fold lower chance of anti-HBs development (OR=0.092, p=0.005), while combined rs3212227 CC and rs360719 TC showed a 4.6-fold lower chance (OR=0.217, p=0.042). The study demonstrates that IL12 and IL18 polymorphisms individually and jointly contribute to anti-HBs development in hemodialysis patients.
About IL18
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
View all IL18 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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