rs36105360
This variant is located in the LMNB1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lamin-B1 measurement
Allele T
OR 0.80
p 2.0e-24
N 3,301
Large GWAS
European
blood protein amount
Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele T
OR 0.50
p 2.0e-21
N 5,330
Large GWAS
European
Emilsson V et al. “Co-regulatory networks of human serum proteins link genetics to disease.” Science (new York, N.y.) 361(6404):769-773 (2018)
Allele T
OR 0.56
p 3.0e-9
N 3,200
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
5 submitters1 publicationnot provided; Adult-onset autosomal dominant demyelinating leukodystrophy; not specified
View on ClinVar →About LMNB1
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
View all LMNB1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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