rs36127550

This variant is located in the ZNF268 gene.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuronal pentraxin-2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.06

p 9.0e-22

N 47,745

Large GWAS

European

coronary artery disease

Tcheandjieu C et al. “Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.” Nature Medicine 28(8):1679-1692 (2022)

Allele T

OR 0.03

p 1.0e-8

N 1,077,578

Large GWAS

multi-ancestry

▶

ClinVar annotation

Benign★★★☆

3 submitters1 publication

not provided; Uterine carcinosarcoma; Melanoma; Thyroid cancer, nonmedullary, 1

View on ClinVar →

About ZNF268

Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; regulation of apoptotic process; and regulation of primary metabolic process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]