rs36138811
This is a upstream gene variant variant in the MANSC4 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
protein measurement
Western D et al. “Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.” Nature Genetics 56(12):2672-2684 (2024)
Allele C
OR 0.68
p 7.0e-134
N 3,506
Large GWAS
European
MANSC domain-containing protein 4 measurement
Allele C
OR 0.64
p 7.0e-117
N 3,301
Large GWAS
European
About MANSC4
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epidermis development; epithelium development; and extracellular matrix organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all MANSC4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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