rs368872847

This variant is located in the PRSS1 gene.

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ClinVar annotation

Likely Benign★★★☆

4 submitters1 publication

not specified; Hereditary pancreatitis

About PRSS1

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

View all PRSS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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