rs369230

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

suntan

Visconti A et al. “Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.” Nature Communications 9(1):1684 (2018)
Allele G
OR 0.47
p —
N 121,296
Large GWAS
European

smoking cessation

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele T
OR 0.01
p 3.0e-10
N 820,192
Large GWAS
European

age at first sexual intercourse measurement

Day FR et al. “Physical and neurobehavioral determinants of reproductive onset and success.” Nature Genetics 48(6):617-623 (2016)
Allele G
OR 0.03
p 7.0e-10
N 125,667
Large GWAS
European

age at initiation of smoking

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 2.0e-9
N 618,541
Large GWAS
European

smoking behavior trait

Wootton RE et al. “Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.” Psychological Medicine 50(14):2435-2443 (2020)
Allele G
OR 0.01
p 2.0e-9
N 462,690
Large GWAS
European

tobacco smoke exposure measurement

Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele T
OR 0.02
p 3.0e-9
N 150,993
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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