rs370763

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Inguinal hernia

Choquet H et al. “Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis.” Human Molecular Genetics 31(13):2279-2293 (2022)
Allele A
OR 1.11
p 1.0e-33
N 513,120
Meta-analysisLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.10
p 1.0e-17
N 623,807
Large GWAS
multi-ancestry
Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele A
OR 1.10
p 6.0e-15
N 275,546
Major Consortium StudyLarge GWAS
European
Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)
Allele A
OR 1.10
p 3.0e-17
N 112,746
Meta-analysisLarge GWAS
European
Jorgenson E et al. “A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.” Nature Communications 6:10130 (2015)
Allele A
OR 1.09
p 4.0e-9
N 72,805
Large GWAS
European

Hernia

Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)
Allele T
OR 1.05
p 8.0e-12
N 375,822
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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