rs372418674

This variant is located in the MS4A6E gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

soluble triggering receptor expressed on myeloid cells 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.36

p 5.0e-17

N 47,745

Large GWAS

European

vitamin B12 measurement

Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)

Allele T

OR 0.23

p 4.0e-10

N 38,000

Large GWAS

South Asian

About MS4A6E

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]

View all MS4A6E variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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