rs3731827

This is a regulatory region variant variant in the VAMP8 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

low affinity immunoglobulin gamma Fc region receptor III-B measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.03

p 2.0e-12

N 47,745

Large GWAS

European

prostate carcinoma

Hoffmann TJ et al. “A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.” Cancer Discovery 5(8):878-91 (2015)

Allele T

OR 1.13

p 1.0e-9

N 46,378

Large GWAS

multi-ancestry

About VAMP8

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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