rs3733897

This variant is located in the TXNDC15 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)

Allele G

OR 0.29

p 2.0e-26

N 5,352

Large GWAS

European

testosterone measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)

Allele A

OR 0.03

p 4.0e-9

N 178,782

Large GWAS

European

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ClinVar annotation

Benign★☆☆☆

2 submitters1 publication

not provided; Adrenocortical carcinoma, hereditary; Colorectal cancer; Cholangiocarcinoma; Uveal melanoma; Malignant lymphoma, large B-cell, diffuse; Uterine carcinosarcoma

View on ClinVar →

About TXNDC15

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided by RefSeq, Apr 2017]