rs3744020
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
white matter hyperintensity measurement
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele A
OR 0.16
p 2.0e-38
N 21,381
Major Consortium StudyLarge GWAS
European
Armstrong NJ et al. “Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.” Stroke 51(7):2111-2121 (2020)
Allele A
OR 0.09
p 7.0e-35
N 18,226
Large GWAS
multi-ancestry
Traylor M et al. “Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).” Neurology 92(8):e749-e757 (2019)
Allele A
OR 0.11
p 1.0e-11
N 11,226
Large GWAS
European
Rutten-Jacobs LCA et al. “Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.” Stroke 49(6):1340-1347 (2018)
Allele A
OR 0.11
p 4.0e-11
N 8,429
Major Consortium StudyLarge GWAS
European
neuroimaging measurement
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele A
OR 0.12
p 3.0e-20
N 21,282
Major Consortium StudyLarge GWAS
European
glomerular filtration rate
Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)
Allele A
OR 5.88
p 4.0e-9
N 1,508,659
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…