rs3744644
This is a protein-altering variant in the SCARF1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
scavenger receptor class F member 1 measurement
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele C
OR 0.69
p 2.0e-12
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
brain aneurysm
Hong EP et al. “Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population.” Journal of Clinical Medicine 8(2) (2019)
Allele G
OR 2.56
p 6.0e-9
N 546
Small GWAS
East Asian
About SCARF1
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
View all SCARF1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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