rs3745191
This is a synonymous variant in the ANO8 gene — it does not change the protein's amino acid sequence.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
triple-negative breast cancer, luminal A breast carcinoma
Sun X et al. “Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer.” Cancer Research 84(15):2533-2548 (2024)
Allele C
OR 0.02
p 4.0e-9
N 77,214
Large GWAS
European
About ANO8
Enables intracellularly calcium-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all ANO8 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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