rs3746187

This variant is located in the PIK3R2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

health study participation

Adams MJ et al. “Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.” International Journal of Epidemiology 49(2):410-421 (2020)
Allele G
OR 0.01
p 1.0e-10
N 371,428
Large GWAS
European
Tyrrell J et al. “Genetic predictors of participation in optional components of UK Biobank.” Nature Communications 12(1):886 (2021)
Allele G
OR 1.03
p 2.0e-10
N 294,787
Major Consortium StudyLarge GWAS
European
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ClinVar annotation

Benign★★★☆
2 submitters1 publication
View on ClinVar →

About PIK3R2

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]

View all PIK3R2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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