rs374678068
This variant is located in the TCTN3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
gut microbiome measurement, bone tissue density
Cheng B et al. “Gut microbiota is associated with bone mineral density : an observational and genome-wide environmental interaction analysis in the UK Biobank cohort.” Bone & Joint Research 10(11):734-741 (2021)
Allele G
OR 0.70
p 9.0e-9
N 2,293
Major Consortium StudyLarge GWAS
European
About TCTN3
This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
View all TCTN3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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