rs3751437

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of complement receptor type 2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.05
p 2.0e-18
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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AssessingFOXO1Aas a potential susceptibility locus for type 2 diabetes and obesity inAmericanIndians
AssociationN=7,710Yunhua L. Muller et al.(2015)· Obesity

In a population-based study of 7710 American Indians, the intronic SNP rs2297627 in FOXO1A associated with early-onset type 2 diabetes (OR=1.34, p=8.7×10^-4) and T2D at any age (OR=1.19, p=1×10^-4), with the risk allele also associated with lower acute insulin secretion (β=0.88, p=0.02). Another intronic SNP rs1334241 (in high LD with rs2297627) associated with maximum adult BMI (β=1.02, p=3×10^-5) and childhood BMI z-score (β=0.08, p=3×10^-4). These findings suggest FOXO1A variation may modestly affect T2D risk and obesity susceptibility in American Indians.

Traits studied:Body fat percentageBody mass indexInsulin secretionObesityType 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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