rs3760128
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele G
OR 0.01
p 8.0e-13
N 1,122,049
Large GWAS
European
Turcot V et al. “Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.” Nature Genetics 50(1):26-41 (2018)
Allele G
OR 0.01
p 1.0e-9
N 526,508
Large GWAS
multi-ancestry
white matter hyperintensity measurement
Jian X et al. “Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.” Stroke 49(8):1812-1819 (2018)
Allele G
OR —
p 7.0e-11
N 3,726
Large GWAS
multi-ancestry
X-16935 measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.07
p 1.0e-9
N 14,296
Large GWAS
European
▶Research that mentions this SNP (1)
▶Genome‐wide association studies of cerebral white matter lesion burdenMeta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology
Genome‐wide association studies of cerebral white matter lesion burden
Meta-analysisN=12,385Fornage M. et al.(2011)· Annals of Neurology
Genome-wide meta-analysis of 9,361 Europeans identified six genome-wide significant SNPs on chromosome 17q25 associated with white matter hyperintensity (WMH) burden. The most significant SNP, rs3744028 (P = 4.0×10⁻⁹ discovery, P = 1.3×10⁻⁷ replication, P = 4.0×10⁻¹⁵ combined), and rs1055129 were replicated in 3,024 additional individuals. Risk alleles increased WMH burden by 4-8% of mean burden.
Traits studied:Cerebral white matter lesionsWhite matter hyperintensities (WMH) burden
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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