rs3762397
This is a intron variant variant in the NR5A2 gene.
▶Research that mentions this SNP (1)
▶Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screeningAssociationN=1,000Zhang YP et al.(2010)· Osteoporosis International
A replication study of 139 SNPs from three prior genome-wide association studies of bone mineral density in an independent sample of 1,000 unrelated US whites confirmed 38 SNPs (27% replication rate). Two SNPs achieved the most significant replication: rs3762397 in NR5A2 and rs3736228 in LRP5. Ten SNPs achieved combined p-values less than 3.6×10⁻⁴ across datasets, including rs3736228 (LRP5) with combined p=5.3×10⁻¹² for spinal BMD.
About NR5A2
The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]
View all NR5A2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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