rs376369757

This variant is located in the ARHGEF12 gene.

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ClinVar annotation

Uncertain Significance★☆☆☆
1 submitter

not specified

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About ARHGEF12

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

View all ARHGEF12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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