rs3764628

This genome-wide association study examined maternal and parent-of-origin genetic effects on orofacial clefts in over 2,000 case-parent triads from an international consortium. While 15 SNPs showed suggestive maternal effects (p<10⁻⁵) and 18 SNPs showed parent-of-origin effects (p<10⁻⁵), including rs17138064 (p=5×10⁻⁷) in the cleft palate group, none survived genome-wide multiple testing correction. The study concluded that neither maternal genotype nor parent-of-origin effects play major roles in isolated orofacial clefting.